Potassium Iodide → Ethyl 2-[4-(acetyloxy)-2-methylphenoxy]-2-methylpropanoate

HRID 9627Notes

Reaction equation

C([C:4]1[CH:18]=[CH:17][C:7]([O:8][C:9]([CH3:16])([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:6]([CH3:19])[CH:5]=1)(=O)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.ClC1C=CC=[C:34]([C:38]([O:40]O)=[O:39])C=1.[I-].[K+]>ClCCl>[C:38]([O:40][C:4]1[CH:18]=[CH:17][C:7]([O:8][C:9]([CH3:15])([CH3:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:6]([CH3:19])[CH:5]=1)(=[O:39])[CH3:34]

Participants

Conditions

Temperature: 40 °C

Procedure

A solution of ethyl 2-(4-acetyl-2-methylphenoxy)-2-methylpropanoate (intermediate 8, 37.33 g) in dichloromethane (650 ml) was treated with 4-toluenesulphonic acid (2.75 g) followed by m-chloroperbenzoic acid (60.5 g) and the mixture warmed to 40° C. and stirred under nitrogen for 19 hours. The cooled mixture was treated with dichloromethane (350 ml) and the resulting mixture added to aqueous potassium iodide (1000 ml, 10% solution). The organic layer was collected and washed twice with water and brine, then dried over sodium sulfate, filtered and the filtrate concentrated to give the title compound as an orange oil.

Workup

customThe organic layer was collected
washwashed twice with water and brine
dry with materialdried over sodium sulfate
filtrationfiltered
concentrationthe filtrate concentrated

Sources & evidence

ORD record: ord-ac4f6997785540cfabd1e40607d0df66
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091237B2

Reaction notes

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