p-Toluenesulfonic acid → 2-Chloro-7-(4-fluorophenyl)-4-(2-methylpyrrolidin-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidine

HRID 96273Notes

Reaction equation

HRID 96273 reaction equation
[CH3:30][CH:31]1[NH:32][CH2:33][CH2:34][CH2:35]1.[Cl:1][c:2]1[n:3][c:4]([Cl:18])[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[O:9][CH2:10]2.[c:19]1([CH3:20])[cH:21][cH:22][c:23]([S:24]([OH:25])(=[O:26])=[O:27])[cH:28][cH:29]1>>[Cl:1][c:2]1[n:3][c:4]([N:32]2[CH:31]([CH3:30])[CH2:35][CH2:34][CH2:33]2)[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[O:9][CH2:10]2

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 130032-MethylpyrrolidineHCID 580754962,4-Dichloro-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidine

Product 1

HCID 766602222-Chloro-7-(4-fluorophenyl)-4-(2-methylpyrrolidin-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidine

Sources & evidence

ORD record
ord-174eda914d02442fa0b7c508f9cdedb7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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