Water → HCID 18913487, compound

HRID 962909Notes

Reaction equation

HRID 962909 reaction equation
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[C:11](=[O:14])([O-])[O-].[K+].[K+]>C1C=CC=CC=1>[C:2]1([C:1]2[S:8][C:2]([CH2:3][CH2:4][CH:11]=[O:14])=[CH:1][N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962Water2×HCID 11430Potassium CarbonateHCID 683563Thiobenzamide

Product 1

HCID 18913487HCID 18913487, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of ethyl formyl β chloracetate in 240 ml of benzene was added to a suspension of 78 g of thiobenzamide in 200 ml of benzene and the mixture was refluxed for 3 hours 30 minutes while eliminating the water formed. The reaction medium was cooled and 320 ml of a 20% solution of potassium carbonate and 220 ml of water were added slowly. Extraction was carried out with ether, followed by washing, drying and distillation under reduced pressure to obtain 75.5 g of the desired product.

Workup

  1. temperaturethe mixture was refluxed for 3 hours 30 minutes
  2. customformed
  3. temperatureThe reaction medium was cooled
  4. extractionExtraction
  5. washby washing
  6. customdrying
  7. distillationdistillation under reduced pressure

Sources & evidence

ORD record
ord-06a8328403034c438b943f204dddf98c
Source dataset
uspto-grants-1998_06
Patent number
US05760233

Reaction notes

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