Potassium Carbonate → HCID 11051953, compound

HRID 963136Notes

Reaction equation

HRID 963136 reaction equation
Br.[NH:2]=[C:3]1[N:7]([CH2:8][CH2:9][CH2:10][F:11])[CH:6]=[CH:5][S:4]1.C(=O)([O-])[O-].[K+].[K+]>O>[NH:2]=[C:3]1[N:7]([CH2:8][CH2:9][CH2:10][F:11])[CH:6]=[CH:5][S:4]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 67658626HCID 67658626, compound

Product 1

HCID 11051953HCID 11051953, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15 g (62.2 mmol) of 2-imino-3-(3-fluoropropyl)thiazoline hydrobromide (4: Z=Br) was dissolved in 150 ml of water, and 8.59 g (62.2 mmol) of anhydrous potassium carbonate was added. The mixture was stirred at room temperature for 10 minutes. The mixture was extracted with 150 ml of chloroform 4 times, and the organic layer was washed with saturated aqueous salt solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 9.45 g of 2-imino-3-(3-fluoropropyl)thiazoline (3) as an oily substance.

Workup

  1. extractionThe mixture was extracted with 150 ml of chloroform 4 times
  2. washthe organic layer was washed with saturated aqueous salt solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-8805a542fc7c40949a2ce7cb4b158599
Source dataset
uspto-grants-1998_06
Patent number
US05763365

Reaction notes

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