5-Bromoisatin → HCID 178516823, compound

HRID 963408Notes

Reaction equation

HRID 963408 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].Cl.[NH2:14][OH:15].C([O-])(=O)C.[Na+]>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[N:14][OH:15])[C:5]2=[O:12]

Participants

5

Reactant 3

HCID 68895-BromoisatinHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Product 1

HCID 178516823HCID 178516823, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.3 g of 5-bromoisatin, 0.8 g of hydroxylamine hydrochloride and 1.6 g of sodium acetate are held at reflux in 50 ml of water for 1.5 hrs. The yellow crystals are filtered off and dried. 2.11 g of 5-bromoisatin oxime are isolated. Yield: 83%. M.p.=215° (decomposition).

Workup

  1. filtrationThe yellow crystals are filtered off
  2. customdried

Sources & evidence

ORD record
ord-145bd8f1889a45d39b43bd775a7e5f43
Source dataset
uspto-grants-1998_06
Patent number
US05763450

Reaction notes

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