Hydrochloric Acid → HCID 19081213, compound

HRID 963493Notes

Reaction equation

HRID 963493 reaction equation
C([O:4][CH2:5][C:6]1[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][N:7]=1)(=O)C.[ClH:16]>>[ClH:16].[OH:4][CH2:5][C:6]1[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19081266HCID 19081266, compound

Product 1

HCID 19081213HCID 19081213, compound

Procedure

A solution of l-acetoxymethyl-5,6,7,8-tetrahydro-isoquinoline (0.44 g) in 6N hydrochloric acid (10 ml) aqueous solution was heated for 4 hours at ca. 100° C. After cooling, the mixture was concentrated in vacuo to give 1-hydroxymethyl-5,6,7,8-tetrahydroisoquinoline hydrochloride (0.42 g) as a brown solid.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a5346eff375f440cac1091cb328ff8b8
Source dataset
uspto-grants-1998_06
Patent number
US05763437

Reaction notes

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