Hydrochloric Acid → Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

HRID 963642Notes

Reaction equation

HRID 963642 reaction equation
C([S:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([O:29]CC)(=[O:28])[O:25]CC)([P:16]([O:21]CC)(=[O:20])[O:17]CC)[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2)(=O)C.Cl>>[SH:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([OH:29])(=[O:25])[OH:28])([P:16]([OH:21])(=[O:17])[OH:20])[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86752760Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester

Product 1

HCID 86752761Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

Procedure

Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester (4.0 mmol) is added to 6N HCl (35 ml) and heated at reflux under nitrogen for 18 hours. The reaction mixture is then cooled and concentrated under reduced pressure. The product is obtained by recrystallizing from water and isopropanol.

Workup

  1. temperatureheated
  2. temperatureat reflux under nitrogen for 18 hours
  3. temperatureThe reaction mixture is then cooled
  4. concentrationconcentrated under reduced pressure
  5. customThe product is obtained
  6. customby recrystallizing from water and isopropanol

Sources & evidence

ORD record
ord-1601c17761b34246994f7fce36b6dcf2
Source dataset
uspto-grants-1998_06
Patent number
US05763611

Reaction notes

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