反应详情

The method of Example 25 was repeated using a Grignard reagent, prepared from 4-fluoro-3-phenoxyphenyl bromide (0.313 g), tetrahydrofuran. (2 ml) and magnesium (24 mg) and 1-(3-acetoxy-2-fluoroprop-1-enyl)-1-(3,4-methylenedioxyphenyl) cyclopropane (Example 22) (0.138 g). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) to afford 1-(2-fluoro-3-(4-fluoro-3-phenoxyphenyl)prop-1-enyl)-1-(3,4-methylenedioxyphenyl)cyclopropane (52 mg, 26%).

1. customThe residue after evaporation
2. customwas purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9)