反应详情

114 g (0.52 mol) of 18 and 103 g (0.58 mol) of N-bromosuccinimide were dissolved in 2000 cm3 of tetrachloromethane at room temperature, 3 g of azobisisobutyronitrile were added, and the mixture was refluxed for 4 hours. The succinimide which precipitated was filtered off, the solvent was removed in vacuo, and the residue was purified by filtration through 1000 g of silica gel (hexane/methylene chloride 9:1), giving 141 g (82%) of 19 as a colorless lachrymatory oil.

1. temperaturethe mixture was refluxed for 4 hours
2. customThe succinimide which precipitated
3. filtrationwas filtered off
4. customthe solvent was removed in vacuo
5. filtrationthe residue was purified by filtration through 1000 g of silica gel (hexane/methylene chloride 9:1)