反应详情

温度

0 °C

A solution of 0.3 g of the aldehyde prepared above in THF (1 mL) was added to a solution of sodium triethylphosphonoacetate prepared by combining triethylphosphonoacetate (0.37 g, 1.2 eq.) and NaH (0.1 g, 50% dispersion, 1.5 eq.) in THF (5 mL) at 0° C. The mixture was stirred at 0° C. for 1 hour and then quenched with saturated ammonium chloride and ethyl acetate. The aqueous layer was extracted twice with ethyl acetate. The combined organic extracts were dried over sodium sulfate and evaporated to give ethyl trans-3, 5-di-t-butylcinnamate as a yellow oil used directly for the next step.

1. customprepared
2. customat 0° C
3. customquenched with saturated ammonium chloride and ethyl acetate
4. extractionThe aqueous layer was extracted twice with ethyl acetate
5. dry with materialThe combined organic extracts were dried over sodium sulfate
6. customevaporated