反应详情

温度

0 °C

To a mixture of the 2-t-butoxycarbonylamino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)propanamide prepared supra (25.1 g, 59.2 mmol) and anisole (12 ml, 110.4 mmol) at 0° C. was added dropwise an aqueous solution of trifluoroacetic acid (118 ml, 1.53 mol) in 50 ml of water. This mixture was stirred for one hour at 0° C., followed by stirring for about 2.5 hours at ambient temperature, The mixture was then refrigerated for about 16 hours.

1. stirringby stirring for about 2.5 hours at ambient temperature
2. waitThe mixture was then refrigerated for about 16 hours