Hydrochloric Acid → HCID 19076186, compound

HRID 965281Notes

Reaction equation

HRID 965281 reaction equation
[OH-].[Na+].[NH2:3][CH:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([C:15]([O:17]C)=[O:16])[CH:13]=[CH:14][C:7]=2[NH:6][C:5]1=[O:19].Cl.[Na+].[Cl-]>O.CO>[NH2:3][CH:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=[CH:14][C:7]=2[NH:6][C:5]1=[O:19]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 19076193HCID 19076193, compound

Product 1

HCID 19076186HCID 19076186, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

A solution of NaOH (0.44 g, 11 mmol) in H2O (12 mL) was added to a suspension of 3amino-7-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 6 (1.72 g, 7.34 mmol) in H2O (100 mL) and MeOH (20 mL). After 5 h the resulting solution was neutralized with HCl (1M, 11 mL) and concentrated to give 7 (2.41 g, theoretically containing approx. 33% NaCl by weight). LRMS (ES), [M+H] m/z=221. ##STR34##

Workup

  1. concentrationconcentrated
  2. customto give 7 (2.41 g

Sources & evidence

ORD record
ord-6016a70660034e2fbc2da924f48ac3cd
Source dataset
uspto-grants-1998_06
Patent number
US05773512

Reaction notes

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