Hydrochloric Acid → HCID 22312933, compound

HRID 965634Notes

Reaction equation

HRID 965634 reaction equation
[C:1]1([N:7]2[C:12](=S)[C:11]([CH2:14][C:15]3[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:16]=3[F:22])=[N:10][NH:9][C:8]2=[O:23])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:24]O.Cl>[OH-].[K+].CO.O>[C:1]1([N:7]2[C:12](=[O:24])[C:11]([CH2:14][C:15]3[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:16]=3[F:22])=[N:10][NH:9][C:8]2=[O:23])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 22313062HCID 22313062, compound

Product 1

HCID 22312933HCID 22312933, compoundYield 85.8%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolvent2×HCID 14797Potassium HydroxideSolvent

Procedure

4-Phenyl-6-(2,6-difluorobenzyl)-5-thioxo-2H-(1,2,4)triazin-3-one (1.00 g, 3.02 mmol) was dissolved in a solution of KOH (643 mg) in MeOH (12 mL) and water (6 mL). A solution of H2O2 (1.2 mL, 30% in water) in water (5 mL) was added and the reaction mixture was stirred at ambient temperature for 30 minutes. The reaction mixture was acidified with conc. HCl (1.1 mL) and a white solid precipitated. Filtered and washed with water to give a white solid (816 mg, 85.8%): MS (CI) m/z 380.2 (MH+).

Workup

  1. customa white solid precipitated
  2. filtrationFiltered
  3. washwashed with water

Sources & evidence

ORD record
ord-36e7e410635d49c0b32bb7dadd695dc0
Source dataset
uspto-grants-2005_10
Patent number
US06951858B2

Reaction notes

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