Hydrochloric Acid → HCID 22037106, compound

HRID 965816Notes

Reaction equation

HRID 965816 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]=2)=[C:4]([CH3:14])[CH:3]=1.[ClH:15]>CCO.[OH-].[OH-].[Pd+2]>[ClH:15].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][NH:12][CH2:11][CH2:10][NH:9]2)=[C:4]([CH3:14])[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22037115HCID 22037115, compound

Product 1

HCID 22037106HCID 22037106, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

2-(4-Fluoro-2-methyl-phenyl)-pyrazine (0.3 g) dissolved in EtOH 95% (20 mL) and 37% HCl (0.2 mL) was hydrogenated at 5 atm. for 4 hr, in the presence of 20% Pd(OH)2/C (30 mg) as catalyst. The catalyst was filtered off and the solvent was evaporated. The crude residue was triturated in MeOH/AcOEt (5 mL/15 mL) to obtain the title compound (0.08 g) as a white powder.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated
  3. customThe crude residue was triturated in MeOH/AcOEt (5 mL/15 mL)

Sources & evidence

ORD record
ord-446848bb628c4100a3ee7ed3fb339b95
Source dataset
uspto-grants-2005_10
Patent number
US06951861B1

Reaction notes

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