Dimethyl Sulfate → HCID 69592051, compound

HRID 965868Notes

Reaction equation

HRID 965868 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N+:11]=2[O-])[CH:5]=[CH:6][CH:7]=1.COS(OC)(=O)=O.[C-:24]#[N:25].[Na+]>CC(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]2[N:11]=[C:12]([C:24]#[N:25])[CH:13]=[CH:14][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 8929Sodium CyanideHCID 69592043HCID 69592043, compound

Product 1

HCID 69592051HCID 69592051, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Following the general method described in example 2b, 2-[2-(3-fluoro-phenyl)-vinyl]-pyridine 1-oxide was reacted first with dimethylsulfate and then with NaCN. After extraction and crystallization the title compound was obtained as a beige crystalline material. Mp. 111-112° C. (iPrOH), MS: m/e=224 (M+).

Workup

  1. extractionAfter extraction and crystallization the title compound
  2. customwas obtained as a beige crystalline material

Sources & evidence

ORD record
ord-23e897bac2584ebc94451d2e254bffbb
Source dataset
uspto-grants-2005_10
Patent number
US06951875B2

Reaction notes

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