Hydrochloric Acid → HCID 22176479, compound

HRID 965881Notes

Reaction equation

HRID 965881 reaction equation
Br[C:2]1[CH2:10][CH2:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.C([Li])(C)(C)C.C([O:19][B:20](OC(C)C)[O:21]C(C)C)(C)C.Cl>C(Cl)Cl.CO>[S:6]1[CH:7]=[CH:8][C:4]2[CH:3]=[C:2]([B:20]([OH:21])[OH:19])[CH2:10][CH2:9][C:5]1=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 21531Triisopropyl borateHCID 22176449HCID 22176449, compoundHCID 178418306HCID 178418306, compound

Product 1

HCID 22176479HCID 22176479, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Following the general method described in example 19a, 5-bromo-6,7-dihydro-benzo[b]thiophene was reacted with tert.-butyllithium solution followed by triisopropylborate and 3N HCl. The title compound was obtained as a white crystalline material after chromatography (SiO2 with CH2Cl2-MeOH=98:2). MS: m/e=179 (M-H−).

Sources & evidence

ORD record
ord-8a61ed098e7945048d2b4728f5b49238
Source dataset
uspto-grants-2005_10
Patent number
US06951875B2

Reaction notes

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