反应详情

To a stirred solution of ethyl trifluoroacetate (500 mg, 3.52 mmol) in tert-butyl methyl ether (4 ml) was added sodium methoxide (28 wt. % solution in methanol; 0.9 ml, 4.0 mmol) over 2 min. A solution of 1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1-ethanone from step 4 (714 mg, 3.33 mmol) in t-butylmethylether (6 ml) was added dropwise over 5 minutes, and the mixture was stirred for 20 hours. 2N HCl (10 ml) was added, and the whole was extracted with ethyl acetate. The organic layer was washed with brine, dried_over MgSO4, and concentrated in vacuo, and the residue was used for next reaction without further purification. (1.05 g, 99% yield).

1. extractionthe whole was extracted with ethyl acetate
2. washThe organic layer was washed with brine, dried_over MgSO4
3. concentrationconcentrated in vacuo
4. customthe residue was used for next reaction without further purification