Water → HCID 940528, compound

HRID 966054Notes

Reaction equation

HRID 966054 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][O:9]2)=[CH:4][CH:3]=1.[H-].[Na+].[C:21](Cl)(=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23].O>CN(C)C=O>[C:21]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][O:9]2)=[CH:4][CH:3]=1)(=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23]

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 62493Pivaloyl chlorideHCID 53768917-Hydroxyisoflavone

Product 1

HCID 940528HCID 940528, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 7 g of 7-hydroxyisoflavone in 190 ml of N,N-dimethylformamide, 2 g of sodium hydride (80% in paraffin oil) were added. The mixture was stirred for 10 minutes, then 4.2 g of pivaloyl chloride were dropped in 1 minute, under vigorous stirring. After 20 minutes at r.t. the mixture was poured into water (400 ml), the precipitate was filtered, washed with water (1000 ml) and dissolved in chloroform (800 ml). The organic solution was dried over sodium sulphate and evaporated to dryness.

Workup

  1. filtrationthe precipitate was filtered
  2. washwashed with water (1000 ml)
  3. dissolutiondissolved in chloroform (800 ml)
  4. dry with materialThe organic solution was dried over sodium sulphate
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-f5097a10b40c494aad37a0c6883a1d3c
Source dataset
uspto-grants-2005_10
Patent number
US06951883B2

Reaction notes

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