反应详情

Oxalyl chloride (4.8 mL, 55 mmol) was added to a solution of 4-oxo-1-phenylcyclohexanecarboxylic acid (Description 2, 6 g, 27 mmol) and dimethylformamide (1 drop) in toluene (150 mL) and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and the residue was dissolved in toluene (100 mL). 3,5-Bis(trifluoromethyl)benzenemethanol (6.25 g, 26 mmol) and 4-dimethylaminopyridine (3.62 g, 30 mmol) were added and the mixture was heated under reflux for 24 hours. The solvent was evaporated under reduced pressure and the residue was partitioned between ethyl acetate (100 mL) and hydrochloric acid (2M, 100 mL). The organic layer was dried (MgSO4) and the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography on silica gel, eluting with isohexane/CH2Cl2 (60:40 increasing to 50:50) to give the title compound (4.5 g, 40%). 1H NMR (360 MHz, CDCl3) δ 2.33-2.53 (6H, m), 2.72-2.77 (2H, m), 5.23 (2H, s), 7.28-7.41 (5H, m), 7.51 (2H, s), and 7.77 (1H, s).

1. customThe solvent was evaporated under reduced pressure and toluene
2. additionwas added
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in toluene (100 mL)
5. temperaturethe mixture was heated
6. temperatureunder reflux for 24 hours
7. customThe solvent was evaporated under reduced pressure
8. customthe residue was partitioned between ethyl acetate (100 mL) and hydrochloric acid (2M, 100 mL)
9. dry with materialThe organic layer was dried (MgSO4)
10. customthe solvent was evaporated under reduced pressure
11. customThe residue was purified by flash column chromatography on silica gel
12. washeluting with isohexane/CH2Cl2 (60:40 increasing to 50:50)