N-Methylallylamine → HCID 178457229, compound

HRID 967178Notes

Reaction equation

HRID 967178 reaction equation
Cl[CH2:2]/[CH:3]=[CH:4]/[C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11][CH2:12][N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:7][CH2:6]1.[CH2:28]([NH:31][CH3:32])[CH:29]=[CH2:30]>CN(C)C(=O)C>[CH2:28]([N:31]([CH3:32])[CH2:2]/[CH:3]=[CH:4]/[C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11][CH2:12][N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:7][CH2:6]1)[CH:29]=[CH2:30]

Participants

4

Reactant 2

HCID 69391N-MethylallylamineHCID 178483624HCID 178483624, compound

Product 1

HCID 178457229HCID 178457229, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-N-{2-[4-(3-chloro-(E)-propenyl)-cyclohexyl]-ethyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide was reacted with N-allyl-methyl-amine in N,N-dimethylacetamide at room temperature to yield trans-N-(2-{4-[3-(allyl-methyl-amino)-(E)-propenyl]-cyclohexyl}-ethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless viscous oil, MS: 459 (MH+).

Sources & evidence

ORD record
ord-2a4195136760443fb9787eeffadf52b9
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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