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HRID967204

反应详情

EQUATION

反应方程式

HRID 967204 的结构方程式

REACTANTS

反应物

2
结构：OC[C@@H]1CCCN1
HCID640091

未命名化合物

结构：CN(C[C@H]1CC[C@H](COCCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
HCID178484054

未命名化合物

PRODUCTS

生成物

1
结构：CN(C[C@H]1CC[C@H](COCCCCN2CCC[C@H]2CO)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
HCID178484061

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

In analogy to the method described in example 12.1, trans-N-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was reacted with (S)-2-hydroxymethyl-pyrrolidine in N,N-dimethylacetamide at room temperature to yield trans-N-{4-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-butoxymethyl]-cyclohexylmethyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless solid, MS: 521 (MH+).