Imidazole → HCID 178483644, compound

HRID 967222Notes

Reaction equation

HRID 967222 reaction equation
[CH3:1][N:2]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:3][CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11]OS(C)(=O)=O)[CH2:7][CH2:6]1.[NH:30]1[CH:34]=[CH:33][N:32]=[CH:31]1.[H-].[Na+]>CN(C)C=O>[N:30]1([CH2:11][C@H:8]2[CH2:9][CH2:10][C@H:5]([CH2:4][CH2:3][N:2]([CH3:1])[S:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH2:6][CH2:7]2)[CH:34]=[CH:33][N:32]=[CH:31]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 24758Sodium hydrideHCID 178483661HCID 178483661, compound

Product 1

HCID 178483644HCID 178483644, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 25.1, trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-ethyl}-cyclohexylmethyl ester (example 13.2) was reacted with imidazole in N,N-dimethylformamide in the presence of sodium hydride to yield trans-N-[2-(4-imidazol-1-ylmethyl-cyclohexyl)-ethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless viscous oil, MS: 430 (MH+).

Sources & evidence

ORD record
ord-a234441b46164c46a3deeb9e1e9cb0e9
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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