Hydrochloric Acid → HCID 22052394, Verbindung

HRID 967454Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967454
C[O:2][C:3](=[O:25])[C:4]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=2[Cl:24])[CH:11]=[C:6]([C:7]([O:9]C)=[O:8])[CH:5]=1.O.O.[OH-].[Li+].Cl>CO>[Cl:24][C:18]1[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:17]=1[CH2:16][CH2:15][O:14][C:12]1[CH:11]=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=[C:4]([CH:13]=1)[C:3]([OH:25])=[O:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 696522995-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester

Produkt 1

HCID 22052394HCID 22052394, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

500 mg 5-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester were dissolved in 50 ml of MeOH:water/3:1. Then 1 g of lithium hydroxide monohydrate was added the solution, and the reaction was stirred at RT for 16 h and 2 h at 50° C. The solution was cooled to RT and then acidified with half-concentrated hydrochloric acid. The suspension was concentrated under reduced pressure and then extracted with ethylacetate. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure to yield a white solid.

Aufarbeitung

  1. temperatureThe solution was cooled to RT
  2. concentrationThe suspension was concentrated under reduced pressure
  3. extractionextracted with ethylacetate
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customthe solvent was removed under reduced pressure
  6. customto yield a white solid

Quellen und Nachweise

ORD-Eintrag
ord-9a9ddd63ef1d4f7abb47be7b5b448736
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06953857B2

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