Hydrochloric Acid → HCID 22052462, compound

HRID 967463Notes

Reaction equation

HRID 967463 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:16]([NH:18][CH2:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:17].[OH-].[Na+].Br[CH2:34][C:35]([OH:37])=[O:36].Cl>CCO.O>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:16]([NH:18][CH2:19][CH:20]1[CH2:25][CH2:24][N:23]([CH2:34][C:35]([OH:37])=[O:36])[CH2:22][CH2:21]1)=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6227Bromoacetic AcidHCID 14798Sodium HydroxideHCID 22052413HCID 22052413, compound

Product 1

HCID 22052462HCID 22052462, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

To 1 g 3-[2-(2,4-Dichloro-phenyl)-ethoxy]-4-methoxy-N-piperidin-4-ylmethyl-benzamide hydrochloride and 400 mg NaOH in 50 ml EtOH/H2O 1:1 0.35 g bromo acetic acid were added at RT. After stirring over night the reaction mixture was acidified with half concentrated HCl. After evaporation of the solvent the residue was coevaporated with toluene. The waxy brown solid was subjected to the subsequent reaction without further purification.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customThe waxy brown solid was subjected to the subsequent reaction without further purification

Sources & evidence

ORD record
ord-8d76db7ff5a242a3bdbf9492bdcd10ae
Source dataset
uspto-grants-2005_10
Patent number
US06953857B2

Reaction notes

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