Hydrochloric Acid → 6623-10-5

HRID 967624Notes

Reaction equation

HRID 967624 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:9][C:10]1[CH:15]=[CH:14]C=[CH:12][CH:11]=1.Cl.[OH-].[Na+]>C(OCC)(=O)C.C(O)C>[CH:2]1([CH:1]2[CH2:14][CH2:15][CH:10]([NH2:9])[CH2:11][CH2:12]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 114192-MethylcyclohexanoneHCID 14798Sodium Hydroxide

Product 1

HCID 2439026623-10-5

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2-methyl-cyclohexanone (112 g, 1.0 mol), aniline (186 g, 2 mol) and ethanol (26 mL) was stirred at room temperature and 12 M hydrochloric acid (167 mL) was added during 30 min. The dark yellow solution was refluxed at 85° C. for seven days. The solution was cooled and diluted with ethyl acetate. The mixture was stirred in an ice bath and made alkaline (pH=9) with a 27% sodium hydroxide solution, keeping the temperature below 30° C.

Workup

  1. temperatureThe dark yellow solution was refluxed at 85° C. for seven days
  2. temperatureThe solution was cooled
  3. stirringThe mixture was stirred in an ice bath
  4. customthe temperature below 30° C.

Sources & evidence

ORD record
ord-1a4083a0f0d945fdb98802adfb61817e
Source dataset
uspto-grants-2005_10
Patent number
US06953812B2

Reaction notes

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