Hydrochloric Acid → HCID 178487770, compound

HRID 967716Notes

Reaction equation

HRID 967716 reaction equation
[NH:1]([C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6])[NH2:2].Cl>O>[CH3:13][O:12][C:10]1[CH:11]=[C:3]2[C:4]([C:5]([OH:6])=[N:2][NH:1]2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22290997HCID 22290997, compound

Product 1

HCID 178487770HCID 178487770, compoundYield 86.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the product from Step A (10.5 g, 48 mmol), water (250 mL), and conc HCl (2.5 mL) was refluxed for 30 min. The volume of the reaction mixture was reduced by evaporation (ca 100 mL) and the pH adjusted to 7 by the slow addition of a saturated aqueous solution of sodium carbonate at room temperature. The solid that formed upon standing was collected and dried to give a gray solid (6.8 g): APCl/LCMS m/z 165 (M+H)+.

Workup

  1. temperaturewas refluxed for 30 min
  2. customThe volume of the reaction mixture was reduced by evaporation (ca 100 mL)
  3. additionthe pH adjusted to 7 by the slow addition of a saturated aqueous solution of sodium carbonate at room temperature
  4. customThe solid that formed
  5. customupon standing was collected
  6. customdried

Sources & evidence

ORD record
ord-710ec96f18104ef5b20f10b0675b692d
Source dataset
uspto-grants-2005_10
Patent number
US06956036B1

Reaction notes

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