Methylamine → HCID 22290499, compound

HRID 967725Notes

Reaction equation

HRID 967725 reaction equation
[F:1][C:2]([F:20])([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]CS([O-])(=O)=O.[CH3:21][NH2:22]>O1CCCC1>[F:1][C:2]([F:20])([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:22][CH3:21]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 22290502HCID 22290502, compound

Product 1

HCID 22290499HCID 22290499, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a solution of 44.7 g of 6,6,7,7,8,8,8-heptafluoro-octylmethanesulfonate in 134 ml of tetrahydrofuran, 41.5 g of methylamine is condensed at −78° C. and stirred for 24 hours at room temperature in a pressurized reactor. Then, it is evaporated to the dry state in a vacuum, washed with water as well as common salt solution, dried on sodium sulfate and evaporated to the dry state in a vacuum. 34.9 g of crude 6,6,7,7,8,8,8-heptafluoro-octyl-methylamine is obtained, and after distillation, 21 g of pure 6,6,7,7,8,8,8-heptafluoro-octyl-methylamine with a boiling point of 89-93° C. at 69 mbar is obtained.

Workup

  1. customcondensed at −78° C.
  2. customThen, it is evaporated to the dry state in a vacuum
  3. washwashed with water as well as common salt solution
  4. customdried on sodium sulfate
  5. customevaporated to the dry state in a vacuum

Sources & evidence

ORD record
ord-585d28737e4c444aa88e51f224a67e04
Source dataset
uspto-grants-2005_10
Patent number
US06956031B2

Reaction notes

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