Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → (2R)-2-[[2-Amino-5-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

HRID 968207Notes

Reaction equation

HRID 968207 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:16]=1.[CH3:17][C:18]1[C:22]([CH2:23]Cl)=[C:21]([CH3:25])[O:20][N:19]=1>>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15][CH2:23][C:22]3[C:18]([CH3:17])=[N:19][O:20][C:21]=3[CH3:25])=[N:6][C:5]=2[N:16]=1

Participants

3

Reactant 2

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 178461804HCID 178461804, compound

Product 1

HCID 86759883(2R)-2-[[2-Amino-5-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

Procedure

The titled compound was prepared from the product of example 4, step (b), and 3,5-dimethyl-4-chloromethylisoxazole using the method of example 4, step (c) to give a white powder (0.016 g)

Sources & evidence

ORD record
ord-c1ee0c372ae340afb77ef8091a29a92c
Source dataset
uspto-grants-2005_10
Patent number
US06958343B2

Reaction notes

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