Hydrochloric Acid → S-(2-Chloroethyl)cysteine--hydrogen chloride (1/1)

HRID 968514Notes

Reaction equation

HRID 968514 reaction equation
[NH2:1][CH:2]([CH2:6][S:7][CH2:8][CH2:9]O)[C:3]([OH:5])=[O:4].[ClH:11]>>[ClH:11].[NH2:1][CH:2]([CH2:6][S:7][CH2:8][CH2:9][Cl:11])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 46107502-Amino-3-(2-hydroxyethylsulfanyl)propanoic acid

Product 1

HCID 24187093S-(2-Chloroethyl)cysteine--hydrogen chloride (1/1)Yield 75.4%

Procedure

33.9 g of 2-amino-3-(2-hydroxy-ethylsulfanyl)-propionic acid was dissolved in 800 mL of concentrated hydrogen chloride and the solution was stirred for 7 h to obtain a buff solid. The solid was recrystallized in isopropanol to obtain a white powder (34.2 g). Yield 75.4%, mp 185-186° C.

Workup

  1. customto obtain a buff solid
  2. customThe solid was recrystallized in isopropanol

Sources & evidence

ORD record
ord-a3566ba2ab3c4afca120512bc7db5aa6
Source dataset
uspto-grants-2007_12
Patent number
US07304057B2

Reaction notes

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