Iodoethane → HCID 131726703, compound

HRID 968645Notes

Reaction equation

HRID 968645 reaction equation
[ClH:1].[CH:2]1([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[O:18][CH3:19])[C:11]([C:20]([N:22]3[CH2:27][CH:26](C)[NH:25][CH:24]([CH3:29])[CH2:23]3)=[O:21])=[CH:10]2)C[CH2:6][CH2:5][CH2:4][CH2:3]1.I[CH2:31][CH3:32]>>[ClH:1].[CH:2]1([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[O:18][CH3:19])[C:11]([C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH2:24][CH3:29])[C@H:31]([CH3:32])[CH2:23]3)=[O:21])=[CH:10]2)[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 131726702HCID 131726702, compound

Product 1

HCID 131726703HCID 131726703, compound

Procedure

(R)-1-{[1-(Cyclopentylmethyl)-7-methoxy-1H-indol-3-yl]carbonyl}-4-ethyl-3-methylpiperazine, hydrochloride salt was prepared using (R)-1-{[1-(cyclopentylmethyl)-7-methoxy-1H-indol-3-yl]carbonyl}-3-methylpiperazine (prepared as detailed in example 12) and iodoethane. 1H NMR (400 MHz, CD3OD) δH 1.24-1.42 (8H, m), 1.51-1.73 (6H, m), 2.43 (1H, heptet, J 7.6), 3.12-3.23 (2H, m), 3.47-3.71 (5H, br m), 3.95 (3H, s), 4.38 (2H, d, J 6.9), 4.51 (2H, br s), 6.77 (1H, d, J 8.2), 7.10 (1H, t, J 7.7), 7.26 (1H, d, J 8.1), 7.60 (1H, s). EIMS; m/z=384.2 [M+H]+.

Sources & evidence

ORD record
ord-7f719ec78e974ba29b9726ad2e41ae74
Source dataset
uspto-grants-2007_12
Patent number
US07304064B2

Reaction notes

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