1,2-Dichloroethane → Tert-butyl 4-[tert-butyl(dimethyl)silyl]oxy-2-[[[2-chloro-4-(4-methoxyphenoxy)pyrimidin-5-yl]amino]methyl]pyrrolidine-1-carboxylate

HRID 96871Notes

Reaction equation

HRID 96871 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH:26]([CH:38]=[O:39])[CH2:27][CH:28]([O:30][Si:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29]1.[CH3:40][C:41](=[O:42])[OH:43].[Cl:1][c:2]1[n:3][cH:4][c:5]([NH2:17])[c:6]([O:8][c:9]2[cH:10][cH:11][c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1.[Cl:44][CH2:45][CH2:46][Cl:47].[Cl:48][CH2:49][Cl:50]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([NH:17][CH2:38][CH:26]2[N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:29][CH:28]([O:30][Si:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:27]2)[c:6]([O:8][c:9]2[cH:10][cH:11][c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 6344DichloromethaneHCID 148639431-Tert-butoxycarbonyl-4-tert-butyldimethylsilyloxy-2-formylpyrrolidineHCID 58243054HCID 58243054, compound

Product 1

HCID 87305967Tert-butyl 4-[tert-butyl(dimethyl)silyl]oxy-2-[[[2-chloro-4-(4-methoxyphenoxy)pyrimidin-5-yl]amino]methyl]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-474af3b35e964390bc5497c3844afc8b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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