Tetrahydrofuran → 1'-benzhydryl-6-(benzyloxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

HRID 96872Notes

Reaction equation

HRID 96872 reaction equation
[C:42](=[O:43])([O-:44])[O-:45].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([OH:38])[c:12]([CH:15]2[C:16](=[O:37])[N:17]([CH:24]([c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[c:18]3[cH:19][cH:20][cH:21][cH:22][c:23]32)[cH:13][cH:14]1.[Cl:39][CH2:40][I:41].[Cs+:46].[Cs+:47].[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:12]([cH:13][cH:14]1)[C:15]1([C:16](=[O:37])[N:17]([CH:24]([c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[c:18]3[cH:19][cH:20][cH:21][cH:22][c:23]31)[CH2:40][O:38]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11644ChloroiodomethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 666724983-[4-(benzyloxy)-2-hydroxyphenyl]-1-(diphenylmethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 461941811'-benzhydryl-6-(benzyloxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

Sources & evidence

ORD record
ord-ccaf8edc5a194e969bfbba30ac40d6d5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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