反应详情

The product from Example 3, Step b (2.00 g) was dissolved in TBF (100 ml) and triethylamine (2.10 g) added. The solution was then cooled with stirring to 0° C. and to it 3-methoxybenzoyl chloride was added dropwise as a solution in THF (10 ml). Reaction was left to warm to room temp and left for 24 hours then water was added and the organics extracted into ethyl acetate. The combined organics were dried with MgSO4 and the solvent removed by evaporation. The crude product was purified by flash chromatography to leave the sub-title product as a pale yellow oil (1.38 g).

1. temperatureThe solution was then cooled
2. customReaction
3. waitwas left
4. extractionthe organics extracted into ethyl acetate
5. dry with materialThe combined organics were dried with MgSO4
6. customthe solvent removed by evaporation
7. customThe crude product was purified by flash chromatography