Trifluoroacetic acid → HCID 69523102, compound

HRID 968769Notes

Reaction equation

HRID 968769 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:28])[C@@H:13]([NH:20]C(=O)OC(C)(C)C)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH2:7]1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12](=[O:28])[C@@H:13]([NH2:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86760587HCID 86760587, compound

Product 1

HCID 69523102HCID 69523102, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 20, step a (0.650 g) was dissolved in dichloromethane (7 ml) and trifluoroacetic acid (2 ml) was added. After 3 hr at room temperature the solution was evaporated and aqueous NaOH (2M) added. The product was extracted with ethyl acetate, the combined organic extracts dried with Na2SO4 and concentrated to give the sub-title product as an oil (0.544 g).

Workup

  1. customAfter 3 hr at room temperature the solution was evaporated
  2. additionaqueous NaOH (2M) added
  3. extractionThe product was extracted with ethyl acetate
  4. dry with materialthe combined organic extracts dried with Na2SO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-46404b04f2a64fb388f5e1c454ca0f8b
Source dataset
uspto-grants-2007_12
Patent number
US07304077B2

Reaction notes

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