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HRID969238

反应详情

EQUATION

反应方程式

HRID 969238 的结构方程式

REACTANTS

反应物

4
反应SMILES：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

反应SMILES：O=C(O)C1(c2ccc(Cl)cc2)CC1
HCID98606

1-(p-Chlorophenyl)cyclopropanecarboxylic acid

C10H9ClO2

反应SMILES：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

反应SMILES：CCC(C)(C)C1(O)CCNC1
HCID66661901

未命名化合物

PRODUCTS

产物

1
反应SMILES：CCC(C)(C)C1(O)CCN(C(=O)C2(c3ccc(Cl)cc3)CC2)C1
HCID66662541

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

3-(1,1-Dimethylpropyl)pyrrolidin-3-ol (29.5 mg, 0.000188 mol) was dissolved in DMF and to this solution were added 1-(4-chlorophenyl)cyclopropanecarboxylic acid (44.3 mg, 0.000225 mol), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (99.6 mg, 0.000225 mol) and N,N-diisopropylethylamine (49 μL, 0.00028 mol), and the resulting solution was stirred at rt overnight. The product was purified by prep-HPLC. LCMS (M+H)=336

WORKUP

后处理

  1. customThe product was purified by prep-HPLC