反应详情

温度

50 °C

To a solution of 8-(1,3-thiazol-5-yl)-1,4-dioxaspiro[4.5]decan-8-ol (0.95 g, 4.14 mmol) in THF (20 mL) was added an aqueous solution of 3 N HCl (10 mL). The mixture was stirred for 1 h at 50° C. After cooling to room temperature, the solution was treated with Na2CO3 to pH 8 and extracted with EtOAc three times. The combined organic layers were washed with saturated NaCl solution, dried (MgSO4), and concentrated to give 0.78 g (98%) of the desired product. MS (M+H)+=198.2.

1. temperatureAfter cooling to room temperature
2. extractionextracted with EtOAc three times
3. washThe combined organic layers were washed with saturated NaCl solution
4. dry with materialdried (MgSO4)
5. concentrationconcentrated