Hydrochloric Acid → HCID 10451932, compound

HRID 969665Notes

Reaction equation

HRID 969665 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[NH:21][CH2:22][C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[CH:11]=2)[C:6]([CH3:31])([CH3:30])[CH2:5]1)(=O)C.Cl>O>[CH3:30][C:6]1([CH3:31])[C:7]2[C:12](=[CH:11][C:10]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[NH:21][CH2:22][C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)=[CH:9][CH:8]=2)[NH:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9823085HCID 9823085, compound

Product 1

HCID 10451932HCID 10451932, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)-amino]-benzamide (Example 2, 120 mg) was heated with HCl (5 N, 2.5 mL) and H2O (2.5 mL) to reflux for 2 h. The solvent was evaporated and the residue was washed with MeOH. The desired compound was collected after filtration as an off-white solid. MS: (ES+) 373 (M+H). Calc'd. for C23H24N4O-372.20.

Workup

  1. temperatureto reflux for 2 h
  2. customThe solvent was evaporated
  3. washthe residue was washed with MeOH
  4. customThe desired compound was collected
  5. filtrationafter filtration as an off-white solid

Sources & evidence

ORD record
ord-e8ef8c8305764a819a3e2a20a8ed4f96
Source dataset
uspto-grants-2007_12
Patent number
US07307088B2

Reaction notes

Loading…