反应详情

温度

48 °C

(4-Dimethoxymethyl-pyrimidin-2-yl)-methylamine (Step A, 3.60 g, 19.6 mmol) and 3 N HCl (14.4 mL, 43.2 mmol) were combined and stirred at 48° C. for 17 h. After cooling to RT, 4.3 g of NaHCO3 was added in portions. The mixture was extracted with EtOAc, the combined organic portions were dried over MgSO4, filtered, and condensed to give the titled compound as a yellow solid. MS (ES+): 138.3 (M+H)+. Calc'd for C6H7N3O-137.14.

1. temperatureAfter cooling to RT
2. extractionThe mixture was extracted with EtOAc
3. dry with materialthe combined organic portions were dried over MgSO4
4. filtrationfiltered
5. customcondensed