Isoamyl Nitrite → HCID 86598711, compound

HRID 969713Notes

Reaction equation

HRID 969713 reaction equation
C([N:4]1[CH:12]=[N:11][C:10]2[C:5]1=[N:6][C:7](N)=[N:8][C:9]=2[I:13])(=O)C.[Br:15][Si](C)(C)C.N(OCCC(C)C)=O>O1CCCC1>[Br:15][C:7]1[N:6]=[C:5]2[C:10]([NH:11][CH:12]=[N:4]2)=[C:9]([I:13])[N:8]=1

Participants

5

Reactant 3

HCID 8053Isoamyl NitriteHCID 76113BromotrimethylsilaneHCID 85871668HCID 85871668, compound

Product 1

HCID 86598711HCID 86598711, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
22.5 °C

Procedure

9-Acetyl-2-amino-6-iodopurine (1.44 g, 4.72 mmol), bromotrimethylsilane (2.17 g, 14.2 mmol) and isoamyl nitrite (0.83 g, 5.67 mmol) were added to tetrahydrofuran (5 ml), and the mixture was stirred 20-25° C. for 19 hr to give 2-bromo-6-iodopurine.

Sources & evidence

ORD record
ord-5cd26d9d638a4514b63677a393bef6e2
Source dataset
uspto-grants-2007_12
Patent number
US07307167B2

Reaction notes

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