p-Toluenesulfonic acid → HCID 178442569, compound

HRID 969745Notes

Reaction equation

HRID 969745 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[O:7]=[C:8](CC1C=CC=CC=1)[CH:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])C([O-])=O.[C:28]1([CH3:38])[CH:33]=[CH:32][C:31](S(O)(=O)=O)=[CH:30][CH:29]=1>>[OH:7][C:8]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[C:38]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:9]=1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 131726714HCID 131726714, compoundHCID 178418311HCID 178418311, compound

Product 1

HCID 178442569HCID 178442569, compound

Procedure

A mixture of 14.0 g (0.17 mol) of 3-amino-1,2,4-triazole, 51.7 g (0.17 mol) of 3-oxo-2-octyl-4-phenylbutanoate and 3. g of p-toluenesulfonic acid was heated under reflux for 6 h. Work-up was carried out analogously to Ex. 1. Drying gave 37 g (0.11 mol) of the title compound.

Workup

  1. temperatureunder reflux for 6 h
  2. customDrying

Sources & evidence

ORD record
ord-ff1917b825a94183b4531878754fc450
Source dataset
uspto-grants-2007_12
Patent number
US07307172B2

Reaction notes

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