Phosphorus oxychloride → HCID 59017637, compound

HRID 969746Notes

Reaction equation

HRID 969746 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]=1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].P(Cl)(Cl)([Cl:27])=O>>[Cl:27][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]=1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178442569HCID 178442569, compound

Product 1

HCID 59017637HCID 59017637, compound

Procedure

A mixture of 17 g (0.05 mol) of 7-hydroxy-6-octyl-5-phenyl-[1,2,4]-triazolo-[1,5-α]-pyrimidine (cf. Ex. 7) and 50 ml of phosphorus oxychloride was heated under reflux for 8 h. Work-up was carried out analogously to Ex. 2. This gave 16 g (0.046 mol) of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 8 h

Sources & evidence

ORD record
ord-a3d5d01d958b4868845f4dd922d29a10
Source dataset
uspto-grants-2007_12
Patent number
US07307172B2

Reaction notes

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