Cyclopentylamine → HCID 59017638, compound

HRID 969747Notes

Reaction equation

HRID 969747 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:15]1[N:20]2[N:21]=[CH:22][N:23]=[C:19]2[N:18]=[C:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:16]=1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>C(Cl)Cl>[CH:1]1([NH:6][C:15]2[N:20]3[N:21]=[CH:22][N:23]=[C:19]3[N:18]=[C:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]=2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 2906CyclopentylamineHCID 8471TriethylamineHCID 59017637HCID 59017637, compound

Product 1

HCID 59017638HCID 59017638, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

With stirring, a mixture of 0.13 g (1.5 mmol) of cyclopentylamine and 0.15 g (1.5 mmol) of triethylamine in 10 ml of methylene chloride was added to a mixture of 0.52 g (1.5 mmol) of 7-chloro-6-octyl-5-phenyl-[1,2,4]-triazolo-[1,5-α]-pyrimidine (cf. Ex. 8) in 20 ml of methylene chloride. The reaction mixture was stirred at room temperature for 16 h, work-up was carried out analogously to Ex. 3. This gave 0.52 g (1.3 mmol) of the title compound (melting point 81° C.).

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 16 h

Sources & evidence

ORD record
ord-1604b688ed2d41b1869a8000a678c966
Source dataset
uspto-grants-2007_12
Patent number
US07307172B2

Reaction notes

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