Hydrochloric Acid → HCID 11525216, compound

HRID 970086Notes

Reaction equation

HRID 970086 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C@H:16]([NH:21][C:22]3[S:23][CH:24]=[C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[N:26]=3)[C:17]([O:19]C)=[O:18])=[CH:11][CH:10]=2)=[C:5]([CH3:33])[O:4][N:3]=1.[Li+].[OH-].Cl.O>C1COCC1.CO.O>[CH3:1][C:2]1[C:6]([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][C@H:16]([NH:21][C:22]3[S:23][CH:24]=[C:25]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[N:26]=3)[C:17]([OH:19])=[O:18])=[CH:13][CH:14]=2)=[C:5]([CH3:33])[O:4][N:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 11669858HCID 11669858, compound

Product 1

HCID 11525216HCID 11525216, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

The crude product from Step B was dissolved in a THF/MeOH/H2O mixture (6:0.1:1; 2 ml). Aqueous 1M LiOH solution (1.6 ml) was added and the mixture was stirred for 3 days at room temperature. Then the reaction mixture was neutralized with 1M HCl, a small amount of water was added, and the mixture extracted with ethyl acetate. The solvent was evaporated.

Workup

  1. extractionthe mixture extracted with ethyl acetate
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-094fb7f562ae4c5e951cf248d4778e1f
Source dataset
uspto-grants-2007_12
Patent number
US07309791B2

Reaction notes

Loading…