4-Hydroxybenzoic Acid → HCID 58935106, compound

HRID 970244Notes

Reaction equation

HRID 970244 reaction equation
C(N(CC)CC)C.[OH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1.[CH2:18]([O:20][CH2:21]Cl)[CH3:19]>ClCCl>[CH2:18]([O:20][CH2:21][O:14][C:13](=[O:15])[C:12]1[CH:16]=[CH:17][C:9]([OH:8])=[CH:10][CH:11]=1)[CH3:19]

Participants

5

Reactant 3

HCID 1354-Hydroxybenzoic AcidHCID 8471TriethylamineHCID 18523Chloromethyl ethyl ether

Product 1

HCID 58935106HCID 58935106, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

36.7 ml (0.26 mole) Of triethylamine were added under a nitrogen atmosphere to a solution of 36.1 g (0.26 mole) of 4-hydroxybenzoic acid in 200 ml of dichloromethane. The mixture was cooled in an ice-water bath, and 24.5 ml (0.26 mole) of chloromethyl ethyl ether in 100 ml of dichloromethane were added dropwise.

Workup

  1. temperatureThe mixture was cooled in an ice-water bath

Sources & evidence

ORD record
ord-f7f2f439edd743b8af62f935d1198322
Source dataset
uspto-grants-2007_12
Patent number
US07311948B2

Reaction notes

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