反应详情

To a solution of 1.0 gm (3.09 mmol) of methyl 3-(3-trifluoromethylbenzamido)benzoate in 19 mL of tetrahydrofuran was added 1.06 mL (30.9 mmol) of hydrazine hydrate. The reaction was heated to reflux for 48 hr. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 785 mg (2.43 mmol, 79% yield) of 3-(3-trifluoromethylbenzamido)benzhydrazide as a white solid. MS m/z: 324.0 (M+H).

1. temperatureThe reaction was heated
2. temperatureto reflux for 48 hr
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
5. additionwere added
6. customThe solid product was separated by filtration
7. customdried in vacuo