Triethylamine → HCID 17986387, compound

HRID 970440Notes

Reaction equation

HRID 970440 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:33])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=1>C(#N)C>[Br:1][C:2]1[C:3]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:33])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 17986359HCID 17986359, compound

Product 1

HCID 17986387HCID 17986387, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 502 mg (2.2 mmol) of 5-bromo-2,4-dichloro-pyrimidine and 0.4 ml of triethylamine (2.3 mmol) in 2.5 ml of acetonitrile is mixed at 0° C. while being stirred with 547 mg (2.3 mmol) of N-(4-amino-butyl)-3-nitro-benzamide. The batch is stirred overnight at room temperature. The precipitate that is formed is suctioned off, washed with water and dried. 574 mg (1.3 mmol, corresponding to 61% of theory) of the product is obtained.

Workup

  1. customThe precipitate that is formed
  2. washwashed with water
  3. customdried
  4. custom574 mg (1.3 mmol, corresponding to 61% of theory) of the product is obtained

Sources & evidence

ORD record
ord-6e4a9f81da304d8cb7f2403086934adf
Source dataset
uspto-grants-2007_12
Patent number
US07312225B2

Reaction notes

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