Triethylamine → HCID 17986379, compound

HRID 970446Notes

Reaction equation

HRID 970446 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22]>C(#N)C>[Br:1][C:2]1[C:3]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 258684-Amino-1-butanolHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 17986379HCID 17986379, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2.28 g (10.0 mmol) of 5-bromo-2,4-dichloro-pyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed at 0° C. with 1.1 ml (12.0 mmol) of 4-amino-butanol. The reaction mixture is slowly heated to room temperature while being stirred by removal of the ice bath. After 16 hours, the precipitate that is formed is filtered off. The filtrate is completely concentrated by evaporation and digested with diisopropyl ether. 2.74 g (9.8 mmol, corresponding to 98% of theory) of the product is obtained.

Workup

  1. customthe precipitate that is formed
  2. filtrationis filtered off
  3. concentrationThe filtrate is completely concentrated by evaporation
  4. custom2.74 g (9.8 mmol, corresponding to 98% of theory) of the product is obtained

Sources & evidence

ORD record
ord-fcc48a2f021b461a9faa5a75d88fac69
Source dataset
uspto-grants-2007_12
Patent number
US07312225B2

Reaction notes

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