反应详情

To a stirred solution of sulfadiazine (192 mg, 0.77 mmol) in dichloromethane (20 mL) were slowly added thiophosgene (0.06 mL, 0.83 mmol) and triethylamine (0.05 mL, 0.32 mmol) under cooling with an ice bath. After the reaction mixture was stirred for five hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum. The product was used immediately for the next reaction.

1. temperatureunder cooling with an ice bath
2. washit was washed with water and brine
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customdried under vacuum
7. customThe product was used immediately for the next reaction