Potassium Carbonate → 2-((benzyloxy)methyl)-2H-tetrazole

HRID 970710Notes

Reaction equation

HRID 970710 reaction equation
[NH:1]1[CH:5]=[N:4][N:3]=[N:2]1.C([O-])([O-])=O.[K+].[K+].Cl[CH2:13][O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CN(C=O)C.O.CCOCC>[CH2:15]([O:14][CH2:13][N:2]1[N:3]=[N:4][CH:5]=[N:1]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

7

Reactant 3

HCID 11430Potassium CarbonateHCID 137983Benzyl chloromethyl etherHCID 178418441HCID 178418441, compound

Product 1

HCID 107263402-((benzyloxy)methyl)-2H-tetrazole

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

To a mixture of tetrazole (1 mmole) and powdered K2CO3 (1.5 mmole) in 1 mL DMF cooled to 0° C. was added benzyl chloromethyl ether (1.2 mmole) and the resulting mixture stirred for 30 min at 0° C. and then for 16 h at rt. The mixture was diluted with water and ether. Extraction and chromatography provided 2-benzyloxymethyltetrazole as a colorless oil.

Workup

  1. waitfor 16 h at rt
  2. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-f3c437dc359740ef91357534946d32a2
Source dataset
uspto-grants-2007_12
Patent number
US07312219B2

Reaction notes

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