反应详情

温度

120 °C

15 g (58 mmol) of 4-bromo-1-ethoxymethoxy-2-ethylbenzene are dissolved in 150 ml of DMF. 26.9 ml (87 mmol) of allyltributyltin are added, and then the mixture is degassed with a nitrogen stream. 1.2 g (1.8 mmol) of dichlorobis (triphenylphosphino)palladium are added, and the medium is heated at 120° C. for 10 hours. The reaction medium is poured into water, and then extracted with ethyl acetate. The residue obtained after drying and concentration is purified by chromatography on a silica column (eluent heptane, and then heptane 95/ethyl acetate 5). A yellow oil is obtained (m=13.6 g, y=100%).

1. customthe mixture is degassed with a nitrogen stream
2. extractionextracted with ethyl acetate
3. customThe residue obtained
4. customafter drying
5. concentrationconcentration
6. customis purified by chromatography on a silica column (eluent heptane
7. customA yellow oil is obtained (m=13.6 g, y=100%)